Lev Salnikov

AntiCA Biomed San Diego, USA

Title: A New Trend In The Field Of Rejuvenation Could Be A Cellular Autocloning

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Biography

Lev Salnikov, MD, PhD, has  many years of experience  in the field of oncology and nuclear medicine. For the last 10 years he has been involved in work related to systems biology and problems of biological bases of aging. In this direction he worked in collaboration with Boston University  and after with Sib Enzyme US LLC, and at the present time with AntiCA Biomed, San Diego, CA 92111.  He has publications in Future Science OA, Frontiers in Aging journals.

Abstract

The main goal of gerontology is to slow down the aging process and eventually stop it. Today, the most promising method to achieve this is cellular reprogramming. The use of regulatory factors that cause the cells to temporarily lose its differentiation, allows them to reverse its epigenetic and biological age.  However, while this method has yielded positive results at the cell culture level, its application at the organismal level faces great difficulties. This is mainly due to the need to deliver such regulatory factors to almost every cell in the body. To overcome the main limitations of this method of rejuvenation we suggest using our proposed direction, called “cells autocloning”. The principle of the proposed rejuvenation method is as follows: a special type of cell nucleus division process is periodically launched in the cell genome with the formation of one unstable daughter copy and its subsequent self-liquidation.  During this process, cell division stops at the nuclei divergence phase without subsequent physical separation of the cell itself. This is especially important for postmitotic cells, where the closing of the “unidirectional” line of their ontogenesis program into a “ring” will mean their transition into renewable cells. The prototype for autocloning mechanisms can be the already known ways by which cells adapt to the increasing volume of their damage over time. These are polyploidy and asymmetric cell division, on the basis of which it is possible to obtain a renewable process of cell nuclei division, when as a result only the original nucleus remains. Cellular autocloning, when initiated, will allow to nullify or stop aging at that “cellular age” when this “division without division” occurs, which is particularly important for non-dividing cells such as neurons.   While this is not a simple task, there are possible pathways to accomplish it using approaches that current knowledge from molecular biology and genetics can suggest.